Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

2023 update on sepsis and septic shock in adult patients: management in the emergency department

M Guarino, B Perna, AE Cesaro, M Maritati… - Journal of clinical …, 2023 - mdpi.com
Background: Sepsis/septic shock is a life-threatening and time-dependent condition that
requires timely management to reduce mortality. This review aims to update physicians with …

SIRS, SOFA, qSOFA, and NEWS in the diagnosis of sepsis and prediction of adverse outcomes: a systematic review and meta-analysis

X Qiu, YP Lei, RX Zhou - Expert review of anti-infective therapy, 2023 - Taylor & Francis
ABSTRACT Background We compared Systemic Inflammatory Response Syndrome (SIRS),
Sequential Organ Failure Assessment (SOFA), Quick Sepsis-related Organ Failure …

Presepsin in the diagnosis of sepsis

T Paraskevas, C Chourpiliadi, S Demiri… - Clinica Chimica …, 2023 - Elsevier
Objectives Sepsis is a life-threatening condition characterized by organ dysfunction. It
occurs due to the host's dysregulated response to an infection. Clinicians use inflammatory …

New insights into the fluid management in patients with septic shock

CD Moschopoulos, D Dimopoulou, A Dimopoulou… - Medicina, 2023 - mdpi.com
The importance of fluid resuscitation therapy during the early stages of sepsis management
is a well-established principle. Current Surviving Sepsis Campaign (SSC) guidelines …

The implication of targeting PD-1: PD-L1 pathway in treating sepsis through immunostimulatory and anti-inflammatory pathways

Y Chen, D Guo, C Zhu, S Ren, C Sun, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Sepsis currently remains a major contributor to mortality in the intensive care unit (ICU), with
48.9 million cases reported globally and a mortality rate of 22.5% in 2017, accounting for …

Norepinephrine may exacerbate septic acute kidney injury: a narrative review

L Al-Husinat, A Alsabbah, AA Hmaid… - Journal of Clinical …, 2023 - mdpi.com
Sepsis, the most serious complication of infection, occurs when a cascade of potentially life-
threatening inflammatory responses is triggered. Potentially life-threatening septic shock is a …

Albumin as a prognostic marker of 30-day mortality in septic patients admitted to the emergency department

G Turcato, A Zaboli, S Sibilio, E Rella, A Bonora… - Internal and Emergency …, 2023 - Springer
Background Assessing the evolutive risk of septic patients in the emergency department
(ED) is very complex. Predictive tools are available, but at an early stage, none of them can …

A time series driven model for early sepsis prediction based on transformer module

Y Tang, Y Zhang, J Li - BMC Medical Research Methodology, 2024 - Springer
Sepsis remains a critical concern in intensive care units due to its high mortality rate. Early
identification and intervention are paramount to improving patient outcomes. In this study …

Plac8-ERK pathway modulation of monocyte function in sepsis

T Zhang, J Fu, G Chen, X Zhang - Cell Death Discovery, 2024 - nature.com
Sepsis, a life-threatening condition caused by infection, is characterized by the
dysregulation of immune responses and activation of monocytes. Plac8, a protein, has been …