Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

An inhalable platform for messenger RNA (mRNA) therapeutics would enable minimally
invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung …

Chemotherapeutic agents have certain limitations when it comes to treating cancer, the most
important being severe side effects along with multidrug resistance developed against them …

Gene therapy has emerged as a promising approach for the treatment or prevention of
acquired and genetic diseases. At the present time, major somatic gene transfer approaches …

The continually increasing wealth of knowledge about the role of genes involved in acquired
or hereditary diseases renders the delivery of regulatory genes or nucleic acids into affected …

Poly (ethylene imine) s (PEIs) are widely used in different applications, but most extensively
investigated as non-viral vector systems. The high ability of cationic PEIs to complex and …

Targeted drug delivery by nanoparticles (NPs) is an essential technique to achieve the ideal
therapeutic effect for cancer. However, it requires large amounts of work to imitate the …

With the development of nanotechnology, various types of polymer-based drug delivery
systems have been designed for biomedical applications. Polymer-based drug delivery …

There is growing interest in PEGylation of cationic polymeric vehicles for gene delivery in
order to improve vehicle stability and reduce toxicity, but little is known about the effects of …