EMT factors and metabolic pathways in cancer
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …
The functional roles of TCA cycle metabolites in cancer
The tricarboxylic acid cycle (TCA cycle) has been known for decades as a hub for
generating cellular energy and precursors for biosynthetic pathways. Several cancers …
generating cellular energy and precursors for biosynthetic pathways. Several cancers …
Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression
Z Li, H Zhang - Cellular and molecular life sciences, 2016 - Springer
Metabolic reprogramming is widely observed during cancer development to confer cancer
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …
How the Warburg effect supports aggressiveness and drug resistance of cancer cells?
P Icard, S Shulman, D Farhat, JM Steyaert… - Drug Resistance …, 2018 - Elsevier
Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …
De novo lipogenesis in health and disease
F Ameer, L Scandiuzzi, S Hasnain, H Kalbacher… - Metabolism, 2014 - Elsevier
Background De novo lipogenesis (DNL) is a complex and highly regulated metabolic
pathway. In normal conditions DNL converts excess carbohydrate into fatty acids that are …
pathway. In normal conditions DNL converts excess carbohydrate into fatty acids that are …
Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
R Ke, Q Xu, C Li, L Luo, D Huang - Cell Biology International, 2018 - Wiley Online Library
AMP‐activated protein kinase (AMPK) is a conserved sensor of cellular energy change and
is activated by increased AMP/ATP and/or ADP/ATP ratios. AMPK maintains the energy …
is activated by increased AMP/ATP and/or ADP/ATP ratios. AMPK maintains the energy …
ATP-citrate lyase controls a glucose-to-acetate metabolic switch
Mechanisms of metabolic flexibility enable cells to survive under stressful conditions and
can thwart therapeutic responses. Acetyl-coenzyme A (CoA) plays central roles in energy …
can thwart therapeutic responses. Acetyl-coenzyme A (CoA) plays central roles in energy …
Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids
N Zaidi, L Lupien, NB Kuemmerle, WB Kinlaw… - Progress in lipid …, 2013 - Elsevier
One of the most important metabolic hallmarks of cancer cells is enhanced lipogenesis.
Depending on the tumor type, tumor cells synthesize up to 95% of saturated and mono …
Depending on the tumor type, tumor cells synthesize up to 95% of saturated and mono …
ATP-citrate lyase: a key player in cancer metabolism
ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA
from citrate. Acetyl CoA is a vital building block for the endogenous biosynthesis of fatty …
from citrate. Acetyl CoA is a vital building block for the endogenous biosynthesis of fatty …
ATP citrate lyase: A central metabolic enzyme in cancer
ACLY links energy metabolism provided by catabolic pathways to biosynthesis. ACLY,
which has been found to be overexpressed in many cancers, converts citrate into acetyl-CoA …
which has been found to be overexpressed in many cancers, converts citrate into acetyl-CoA …