The fabrication of biomimetic catalysts as substituents for enzymes is of critical interest in the
field due to the problems associated with the extraction, purification, and storage of enzymes …

Heme is a cofactor that is essential to almost all forms of life. The production of heme is a
balancing act between the generation of the requisite levels of the end-product and …

Abstract Changes in ε 393 (the Soret band) of aqueous ferriprotoporphyrin IX [Fe (III) PPIX]
with concentration indicate that it dimerizes, but does not form higher aggregates. Diffusion …

Abstract β-Hematin, the metalloporphyrin coordination polymer present in malaria pigment,
is prepared in high yield by the abstraction of HCl from hemin with a non-coordinating base …

Anemia resulting from iron deficiency is one of the most prevalent diseases in the world. As
iron has important roles in several biological processes such as oxygen transport, DNA …

Expression levels in animal muscle tissues and in Escherichia coli vary widely for naturally
occurring mammalian myoglobins (Mb). To explore this variation, we developed an in vitro …

MF6p/FhHDM-1 is a small protein secreted by the parasitic flatworm (trematode) Fasciola
hepatica that belongs to a broad family of heme-binding proteins (MF6p/helminth defense …

CHARMM force field parameters have been developed to model nonprotein bound five-
coordinate ferriheme (ferriprotoporphyrin IX) species in aqueous solution. Structures and …

Aberrant protein folding and formation of amyloid fibrils are associated with numerous
debilitating human diseases, for which there are currently no suitable therapeutic treatments …

The effects of solvents on the conformation of hemin and their implications on the dynamics
of the complex have been studied using the time-resolved optical Kerr effect (OKE) with 35 fs …