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Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
[HTML][HTML] Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …
Map** spatially resolved transcriptomes in human and mouse pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and
limited treatment options. Efforts to identify effective treatments are thwarted by limited …
limited treatment options. Efforts to identify effective treatments are thwarted by limited …
Immune mechanisms of pulmonary fibrosis with bleomycin
Fibrosis and structural remodeling of the lung tissue can significantly impair lung function,
often with fatal consequences. The etiology of pulmonary fibrosis (PF) is diverse and …
often with fatal consequences. The etiology of pulmonary fibrosis (PF) is diverse and …
An official American Thoracic Society workshop report: use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis
Numerous compounds have shown efficacy in limiting development of pulmonary fibrosis
using animal models, yet few of these compounds have replicated these beneficial effects in …
using animal models, yet few of these compounds have replicated these beneficial effects in …
Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis
Rationale: Dysregulation of cellular metabolism has been shown to participate in several
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …
The bleomycin model of pulmonary fibrosis
T Liu, FG De Los Santos, SH Phan - Fibrosis: Methods and Protocols, 2017 - Springer
Interstitial lung disease (ILD) comprises a large number of chronic lung disease
characterized by varying degrees of inflammation and fibrosis. Mostly they are idiopathic …
characterized by varying degrees of inflammation and fibrosis. Mostly they are idiopathic …
Exploring animal models that resemble idiopathic pulmonary fibrosis
J Tashiro, GA Rubio, AH Limper, K Williams… - Frontiers in …, 2017 - frontiersin.org
Large multicenter clinical trials have led to two recently approved drugs for patients with
idiopathic pulmonary fibrosis (IPF); yet, both of these therapies only slow disease …
idiopathic pulmonary fibrosis (IPF); yet, both of these therapies only slow disease …
The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases
Chemokines are small proteins that control several tissue functions, including cell
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …
Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …