Evolutionarily divergent mTOR remodels translatome for tissue regeneration

O Zhulyn, HD Rosenblatt, L Shokat, S Dai… - Nature, 2023 - nature.com
An outstanding mystery in biology is why some species, such as the axolotl, can regenerate
tissues whereas mammals cannot. Here, we demonstrate that rapid activation of protein …

Nutrition-and hormone-controlled developmental plasticity in Blattodea

F Liu, S Yu, N Chen, C Ren, S Li - Current Opinion in Insect Science, 2023 - Elsevier
Highlights•The IIS/TORC1 and MEKRE93 pathways coordinately regulate body size by
regulating nymphal growth, molting, and metamorphosis;•Blattodea insects have evolved …

To regenerate or not to regenerate: Vertebrate model organisms of regeneration‐competency and‐incompetency

C Aztekin, MA Storer - Wound Repair and Regeneration, 2022 - Wiley Online Library
Why only certain species can regenerate their appendages (eg tails and limbs) remains one
of the biggest mysteries of nature. Unlike anuran tadpoles and salamanders, humans and …

A novel approach to comparative RNA-seq does not support a conserved set of orthologs underlying animal regeneration

NC Sierra, N Olsman, L Yi, L Pachter… - Genome Biology and …, 2024 - academic.oup.com
Molecular studies of animal regeneration typically focus on conserved genes and signaling
pathways that underlie morphogenesis. To date, a holistic analysis of gene expression …

Evolution and Function of the Notch Signaling Pathway: An Invertebrate Perspective

Y Lv, X Pang, Z Cao, C Song, B Liu, W Wu… - International Journal of …, 2024 - mdpi.com
The highly conserved Notch signaling pathway affects embryonic development,
neurogenesis, homeostasis, tissue repair, immunity, and numerous other essential …

Insulin-like signaling promotes limb regeneration in the Chinese mitten crab (Eriocheir sinensis)

J Li, Y Tian, X Li, J Zuo, R Zhao, J Sun - Fish & Shellfish Immunology, 2022 - Elsevier
In the pond culture of Chinese mitten crabs, limb autotomy seriously affects the feeding
efficiency, immunity and survival. Therefore, it is crucial to understand the mechanism of limb …

Toeing the line between regeneration and fibrosis

V Jou, JA Lehoczky - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Understanding the remarkable capacity of vertebrates to naturally regenerate injured body
parts has great importance for potential translation into human therapeutic applications. As …

The microbiome of a Pacific moon jellyfish Aurelia coerulea

AH Ohdera, M Mansbridge, M Wang, P Naydenkov… - Plos one, 2024 - journals.plos.org
The impact of microbiome in animal physiology is well appreciated, but characterization of
animal-microbe symbiosis in marine environments remains a growing need. This study …

Mammalian organ regeneration in spiny mice

DM Okamura, ED Nguyen, SJ Collins, K Yoon… - Journal of Muscle …, 2023 - Springer
Fibrosis-driven solid organ failure is a major world-wide health burden with few therapeutic
options. Spiny mice (genus: Acomys) are terrestrial mammals that regenerate severe skin …

Multiphysics discovery with moving boundaries using Ensemble SINDy and peridynamic differential operator

AC Bekar, E Haghighat, E Madenci - Engineering with Computers, 2024 - Springer
This study proposes a novel framework for learning the underlying physics of phenomena
with moving boundaries. The proposed approach combines Ensemble SINDy and …