Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Axonal transport is the process whereby motor proteins actively navigate microtubules to
deliver diverse cargoes, such as organelles, from one end of the axon to the other, and is …

Axonal transport is essential for neuronal function, and many neurodevelopmental and
neurodegenerative diseases result from mutations in the axonal transport machinery …

Alzheimer's disease (AD) is characterized by amyloid plaques composed of the β-amyloid
(Aβ) peptide surrounded by swollen presynaptic dystrophic neurites consisting of …

The endocytic pathway is essential for processes that define how cells interact with their
environment, including receptor signalling, cell adhesion and migration, pathogen entry …

Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth
of new structural, mechanistic, and cell biological data is shedding light on how this …

Peripheral neuropathy is a common complication of a variety of diseases and treatments,
including diabetes, cancer chemotherapy, and infectious causes (HIV, hepatitis C, and …

Microtubule-based transport is essential for neuronal function because of the large
distances that must be traveled by various building blocks and cellular materials. Recent …

Motor-cargo recruitment to microtubules is often the rate-limiting step of intracellular
transport, and defects in this recruitment can cause neurodegenerative disease. Here, we …

Post‐translational modifications (PTM s) of α/β‐tubulin are believed to regulate interactions
with microtubule‐binding proteins. A well‐characterized PTM involves in the removal and re …