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The single-cell immunogenomic landscape of B and plasma cells in early-stage lung adenocarcinoma
Tumor-infiltrating B and plasma cells (TIB) are prevalent in lung adenocarcinoma (LUAD);
however, they are poorly characterized. We performed paired single-cell RNA and B-cell …
however, they are poorly characterized. We performed paired single-cell RNA and B-cell …
[PDF][PDF] Clonal evolution in healthy and premalignant tissues: implications for early cancer interception strategies
Histologically normal human tissues accumulate significant mutational burden with age. The
extent and spectra of mutagenesis are comparable both in rapidly proliferating and post …
extent and spectra of mutagenesis are comparable both in rapidly proliferating and post …
Resolving the spatial and cellular architecture of lung adenocarcinoma by multiregion single-cell sequencing
Little is known of the geospatial architecture of individual cell populations in lung
adenocarcinoma (LUAD) evolution. Here, we perform single-cell RNA sequencing of …
adenocarcinoma (LUAD) evolution. Here, we perform single-cell RNA sequencing of …
Game of clones: Battles in the field of carcinogenesis
Recent advances in bulk sequencing approaches as well as genomic decoding at the single-
cell level have revealed surprisingly high somatic mutational burdens in normal tissues, as …
cell level have revealed surprisingly high somatic mutational burdens in normal tissues, as …
Precancer atlas to drive precision prevention trials
Cancer development is a complex process driven by inherited and acquired molecular and
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …
AACR white paper: sha** the future of cancer prevention–a roadmap for advancing science and public health
The recent pace, extent, and impact of paradigm-changing cancer prevention science has
been remarkable. The American Association for Cancer Research (AACR) convened a 3 …
been remarkable. The American Association for Cancer Research (AACR) convened a 3 …
Driver mutations in normal airway epithelium elucidate spatiotemporal resolution of lung cancer
Rationale: Uninvolved normal-appearing airway epithelium has been shown to exhibit
specific mutations characteristic of nearby non–small cell lung cancers (NSCLCs). Yet, its …
specific mutations characteristic of nearby non–small cell lung cancers (NSCLCs). Yet, its …
Relating evolutionary selection and mutant clonal dynamics in normal epithelia
Cancer develops from mutated cells in normal tissues. Whether somatic mutations alter
normal cell dynamics is key to understanding cancer risk and guiding interventions to …
normal cell dynamics is key to understanding cancer risk and guiding interventions to …
Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung
Background Genomic investigation of atypical adenomatous hyperplasia (AAH), the only
known precursor lesion to lung adenocarcinomas (LUAD), presents challenges due to the …
known precursor lesion to lung adenocarcinomas (LUAD), presents challenges due to the …
Advancements in the diagnosis and treatment of sub‑centimeter lung cancer in the era of precision medicine
X Wang, J Shi, Z Liu - Molecular and clinical oncology, 2024 - spandidos-publications.com
Lung cancer is the malignancy with the highest global mortality rate and imposes a
substantial burden on society. The increasing popularity of lung cancer screening has led to …
substantial burden on society. The increasing popularity of lung cancer screening has led to …