Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …

Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

Regulating the emergence of leaders is a central aspect of collective cell migration, but the
underlying mechanisms remain ambiguous. Here we show that the selective emergence of …

In this article, we review physics-based models of collective cell motility. We discuss a range
of techniques at different scales, ranging from models that represent cells as simple self …

We review recent evidence showing that cell and tissue dynamics are governed by
mesoscale physical principles. These principles can be understood in terms of simple state …

Coordinated motions of close-packed multicellular systems typically generate cooperative
packs, swirls, and clusters. These cooperative motions are driven by active cellular forces …

Live tissues can self‐organize and be described as active materials composed of cells that
generate active stresses through continuous injection of energy. In vitro reconstituted …

Collective cell migration occurs in many patho-physiological states, including wound healing
and invasive cancer growth. The integrity of the expanding epithelial sheets depends on …

Mathematical and computational models can assist in gaining an understanding of cell
behavior at many levels of organization. Here, we review models in the literature that focus …

The ability of cells to move in a mechanically coupled, coordinated manner, referred to as
collective cell migration, is central to many developmental, physiological, and …