[HTML][HTML] Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

DV Bhalani, B Nutan, A Kumar, AK Singh Chandel - Biomedicines, 2022 - mdpi.com
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Intraperitoneal route of drug administration: should it be used in experimental animal studies?

A Al Shoyaib, SR Archie, VT Karamyan - Pharmaceutical research, 2020 - Springer
Intraperitoneal (IP) route of drug administration in laboratory animals is a common practice
in many in vivo studies of disease models. While this route is an easy to master, quick …

Senolytics reduce coronavirus-related mortality in old mice

CD Camell, MJ Yousefzadeh, Y Zhu, LGPL Prata… - Science, 2021 - science.org
INTRODUCTION The COVID-19 pandemic revealed enhanced vulnerability of the elderly
and chronically ill to adverse outcomes upon severe acute respiratory syndrome coronavirus …

[HTML][HTML] Role of the encapsulation in bioavailability of phenolic compounds

J Grgić, G Šelo, M Planinić, M Tišma, A Bucić-Kojić - Antioxidants, 2020 - mdpi.com
Plant-derived phenolic compounds have multiple positive health effects for humans
attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These …

Nanoemulsion: Concepts, development and applications in drug delivery

Y Singh, JG Meher, K Raval, FA Khan… - Journal of controlled …, 2017 - Elsevier
Nanoemulsions are biphasic dispersion of two immiscible liquids: either water in oil (W/O) or
oil in water (O/W) droplets stabilized by an amphiphilic surfactant. These come across as …

Techniques for formulation of nanoemulsion drug delivery system: A review

M Kumar, RS Bishnoi, AK Shukla… - Preventive nutrition and …, 2019 - pmc.ncbi.nlm.nih.gov
Nanoemulsion drug delivery systems are advanced modes for delivering and improving the
bioavailability of hydrophobic drugs and the drug which have high first pass metabolism …

Opportunities and challenges in enhancing the bioavailability and bioactivity of dietary flavonoids: A novel delivery system perspective

D Yuan, Y Guo, F Pu, C Yang, X **ao, H Du, J He, S Lu - Food Chemistry, 2024 - Elsevier
Flavonoids have multiple favorable bioactivities including antioxidant, anti-inflammatory, and
antitumor. Currently, flavonoid-containing dietary supplements are widely tested in clinical …

Fisetin in cancer: attributes, developmental aspects, and nanotherapeutics

RM Kumar, H Kumar, T Bhatt, R Jain, K Panchal… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major causes of mortality, globally. Cancerous cells invade normal cells
and metastasize to distant sites with the help of the lymphatic system. There are several …

Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H **ng, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

[HTML][HTML] Application of nanoparticles in cancer treatment: a concise review

M Sell, AR Lopes, M Escudeiro, B Esteves… - Nanomaterials, 2023 - mdpi.com
Timely diagnosis and appropriate antitumoral treatments remain of utmost importance, since
cancer remains a leading cause of death worldwide. Within this context, nanotechnology …