Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021‏ - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release

J Liu, H Cabral, P Mi - Advanced Drug Delivery Reviews, 2024‏ - Elsevier
The cellular barriers are major bottlenecks for bioactive compounds entering into cells to
accomplish their biological functions, which limits their biomedical applications …

[HTML][HTML] Nano-based approved pharmaceuticals for cancer treatment: Present and future challenges

F Rodríguez, P Caruana, N De la Fuente, P Español… - Biomolecules, 2022‏ - mdpi.com
Cancer is one of the main causes of death worldwide. To date, and despite the advances in
conventional treatment options, therapy in cancer is still far from optimal due to the non …

Converting nanotoxicity data to information using artificial intelligence and simulation

X Yan, T Yue, DA Winkler, Y Yin, H Zhu… - Chemical …, 2023‏ - ACS Publications
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …

Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers

S Mazumdar, D Chitkara, A Mittal - Acta Pharmaceutica Sinica B, 2021‏ - Elsevier
The beneficial or deleterious effects of nanomedicines emerge from their complex
interactions with intracellular pathways and their subcellular fate. Moreover, the dynamic …

Form follows function: nanoparticle shape and its implications for nanomedicine

C Kinnear, TL Moore, L Rodriguez-Lorenzo… - Chemical …, 2017‏ - ACS Publications
This review is a comprehensive description of the past decade of research into
understanding how the geometry and size of nanoparticles affect their interaction with …

[HTML][HTML] Small tech, big impact: Agri-nanotechnology journey to optimize crop protection and production for sustainable agriculture

A Singh, VD Rajput, A Varshney, K Ghazaryan… - Plant Stress, 2023‏ - Elsevier
The world's climate shifts rapidly, leading to increasingly severe and volatile weather,
negatively impacting crop yields. To produce long-lasting crops, cutting-edge …

Nanoparticle cellular internalization is not required for RNA delivery to mature plant leaves

H Zhang, NS Goh, JW Wang, RL Pinals… - Nature …, 2022‏ - nature.com
Rapidly growing interest in the nanoparticle-mediated delivery of DNA and RNA to plants
requires a better understanding of how nanoparticles and their cargoes translocate in plant …

Physical principles of nanoparticle cellular endocytosis

S Zhang, H Gao, G Bao - ACS nano, 2015‏ - ACS Publications
This review article focuses on the physiochemical mechanisms underlying nanoparticle
uptake into cells. When nanoparticles are in close vicinity to a cell, the interactions between …

Entry of nanoparticles into cells: The importance of nanoparticle properties

J Zhao, MH Stenzel - Polymer Chemistry, 2018‏ - pubs.rsc.org
Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great
importance for the design of safe and efficient nanomedicines. Extensive studies aimed at …