Context-dependent functions of pattern recognition receptors in cancer
SM Man, BJ Jenkins - Nature Reviews Cancer, 2022 - nature.com
The immune system plays a critical role in sha** all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …
initiation stage through to metastatic disease and resistance to therapy. Our understanding …
Radiogenomics in renal cancer management—current evidence and future prospects
Renal cancer management is challenging from diagnosis to treatment and follow-up. In
cases of small renal masses and cystic lesions the differential diagnosis of benign or …
cases of small renal masses and cystic lesions the differential diagnosis of benign or …
[HTML][HTML] New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia
Abstract The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …
neoplasia, particularly post-2016 World Health Organization (WHO) classification, to provide …
Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer
Molecular routes to metastatic dissemination are critical determinants of aggressive cancers.
Through in vivo CRISPR–Cas9 genome editing, we generated somatic mosaic genetically …
Through in vivo CRISPR–Cas9 genome editing, we generated somatic mosaic genetically …
Proteogenomic characterization of MiT family translocation renal cell carcinoma
Y Qu, X Wu, A Anwaier, J Feng, W Xu, X Pei… - Nature …, 2022 - nature.com
Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is
a rare type of kidney cancer, which is not well characterized. Here we show the …
a rare type of kidney cancer, which is not well characterized. Here we show the …
[HTML][HTML] The impact of hypoxia on tumor-mediated bypassing anti-PD-(L) 1 therapy
K Mortezaee, J Majidpoor, E Kharazinejad - Biomedicine & …, 2023 - Elsevier
Extending the durability of response is the current focus in cancer immunotherapy with
immune checkpoint inhibitors (ICIs). However, factors like non-immunogenic tumor …
immune checkpoint inhibitors (ICIs). However, factors like non-immunogenic tumor …
Proteogenomic characterization of skull-base chordoma
Q Zhang, Z Xu, R Han, Y Wang, Z Ye, J Zhu… - Nature …, 2024 - nature.com
Skull-base chordoma is a rare, aggressive bone cancer with a high recurrence rate. Despite
advances in genomic studies, its molecular characteristics and effective therapies remain …
advances in genomic studies, its molecular characteristics and effective therapies remain …
SMARCB1-deficient cancers: novel molecular insights and therapeutic vulnerabilities
Simple Summary Loss of SMARCB1 has been identified as the sole mutation in a number of
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …
Clinico-pathological implications of the 2022 WHO Renal Cell Carcinoma classification
The new WHO classification of urogenital tumours published in 2022, contains significant
revisions upon the previous 2016 version regarding Renal Cell Carcinoma (RCC). While the …
revisions upon the previous 2016 version regarding Renal Cell Carcinoma (RCC). While the …
Checkpoint Immunotherapy in Pediatrics: Here, Gone, and Back Again.
The role of immune checkpoint inhibitors (ICIs) in the treatment of pediatric cancers
continues to evolve. Such therapies function by augmenting existing antitumor T-cell …
continues to evolve. Such therapies function by augmenting existing antitumor T-cell …