Ischemia‐reperfusion injury (IRI) results in irreversible metabolic dysfunction and structural
damage to tissues or organs, posing a formidable challenge in the field of organ …

Mesenchymal stem cells (MSCs) originate from many sources, including the bone marrow
and adipose tissue, and differentiate into various cell types, such as osteoblasts and …

Abstract NIMA‐related kinase 2 (NEK2) is a serine/threonine protein kinase that regulates
mitosis and plays pivotal roles in cell cycle regulation and DNA damage repair. However, its …

The enhancement of bioactivity in materials has become an important focus within the field
of bone tissue engineering. Four-dimensional intelligent osteogenic module, an innovative …

Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis due to late detection and
limited treatment options. Some PDAC patients harbor alterations that qualify for targeted …

Background Osteoporosis, a prevalent bone disorder, results in reduced bone mineral
density and mass. With minimal side effects, medicinal plant-based natural remedies are …

The safe and effective use of Wnt signaling is a hot topic in develo** osteogenic drugs.
SB216763 (S33) is a widely used highly specific GSK3β inhibitor. Here, we show that S33 …

Simple Summary In this study, we screened key signaling pathways regulating the formation
of chicken PGCs using transcriptome sequencing and established a two-step induction …

Finding a bone implant that has high bioactivity that can safely drive stem cell differentiation
and simulate a real in vivo microenvironment is a challenge for bone tissue engineering …

Purpose: The safety, pharmacokinetics, and efficacy of elraglusib, a glycogen synthase
kinase-3β (GSK-3β) small-molecule inhibitor, as monotherapy or combined with …