The skin is the outermost organ of the body and is continuously exposed to external
pathogens. Upon inflammation, various immune cells pass through, reside in or are …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Over the past decade, it has become clear that there is an important subset of memory T
cells that resides in tissues—tissue-resident memory T (TRM) cells. There is an emerging …

Atopic dermatitis (AD) is a common skin condition, characterized by a complex,
heterogeneous pathogenesis, including skin barrier dysfunctions, allergy/immunology, and …

Skin is the largest organ of the body with a complex network of multitude of cell types that
perform plastic and dynamic cellular communication to maintain several vital processes …

Central memory T (TCM) cells in lymph nodes (LNs) and resident memory T (TRM) cells in
peripheral tissues have distinct roles in protective immunity,,,,. Both are generated after …

Background Allergic contact dermatitis (ACD) is the most common occupational disease.
Although murine contact hypersensitivity provides a framework for understanding ACD, it …

Allergic contact dermatitis is a common skin disease associated with inflammation and
persistent pruritus. Transient receptor potential (TRP) ion channels in skin-innervating …

It remains largely unclear how antigen-presenting cells (APCs) encounter effector or
memory T cells efficiently in the periphery. Here we used a mouse contact hypersensitivity …

IL-1 family member IL-37 limits innate inflammation in models of colitis and LPS-induced
shock, but a role in adaptive immunity remains unknown. Here, we studied mice expressing …