Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

CW Hall, TF Mah - FEMS microbiology reviews, 2017‏ - academic.oup.com
Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix
that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic …

Structure, function and regulation of Pseudomonas aeruginosa porins

S Chevalier, E Bouffartigues, J Bodilis… - FEMS microbiology …, 2017‏ - academic.oup.com
Pseudomonas aeruginosa is a Gram-negative bacterium belonging to the γ-proteobacteria.
Like other members of the Pseudomonas genus, it is known for its metabolic versatility and …

Two-component systems required for virulence in Pseudomonas aeruginosa

VI Francis, EC Stevenson, SL Porter - FEMS microbiology letters, 2017‏ - academic.oup.com
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad
range of hosts, in addition to thriving in a broad range of environmental conditions outside of …

An integrated genomic regulatory network of virulence-related transcriptional factors in Pseudomonas aeruginosa

H Huang, X Shao, Y **e, T Wang, Y Zhang… - Nature …, 2019‏ - nature.com
The virulence of Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, is
regulated by many transcriptional factors (TFs) that control the expression of quorum …

[HTML][HTML] Two component regulatory systems and antibiotic resistance in Gram-negative pathogens

AY Bhagirath, Y Li, R Patidar, K Yerex, X Ma… - International journal of …, 2019‏ - mdpi.com
Gram-negative pathogens such as Klebsiella pneumoniae, Acinetobacter baumannii, and
Pseudomonas aeruginosa are the leading cause of nosocomial infections throughout the …

From input to output: the Lap/c-di-GMP biofilm regulatory circuit

AJ Collins, TJ Smith, H Sondermann… - Annual review of …, 2020‏ - annualreviews.org
Biofilms are the dominant bacterial lifestyle. The regulation of the formation and dispersal of
bacterial biofilms has been the subject of study in many organisms. Over the last two …

Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence

G Rampioni, CR Pillai, F Longo, R Bondì, V Baldelli… - Scientific reports, 2017‏ - nature.com
Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic
resistance in many bacterial pathogens, representing candidate targets for the development …

The Rhl quorum-sensing system is at the top of the regulatory hierarchy under phosphate-limiting conditions in Pseudomonas aeruginosa PAO1

MP Soto-Aceves, M Cocotl-Yañez… - Journal of …, 2021‏ - journals.asm.org
Pseudomonas aeruginosa is a major nosocomial pathogen that presents high-level
resistance to antibiotics. Its ability to cause infections relies on the production of multiple …

Extracytoplasmic function sigma factors in Pseudomonas aeruginosa

S Chevalier, E Bouffartigues, A Bazire… - … et Biophysica Acta (BBA …, 2019‏ - Elsevier
The opportunistic pathogen Pseudomonas aeruginosa, like all members of the genus
Pseudomonas, has the capacity to thrive in very different environments, ranging from water …

An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

T Wang, W Sun, L Fan, C Hua, N Wu, S Fan, J Zhang… - Elife, 2021‏ - elifesciences.org
A high-throughput systematic evolution of ligands by exponential enrichment assay was
applied to 371 putative TFs in Pseudomonas aeruginosa, which resulted in the robust …