Next-generation sequencing has made major strides in the past decade. Studies based on
large sequencing data sets are growing in number, and public archives for raw sequencing …

Since the completion of the Human Genome project at the turn of the Century, there has
been an unprecedented proliferation of genomic sequence data. A consequence of this is …

Genomics is a Big Data science and is going to get much bigger, very soon, but it is not
known whether the needs of genomics will exceed other Big Data domains. Projecting to the …

Duchenne muscular dystrophy (DMD) is a severe muscle-degenerative disease caused by a
mutation in the dystrophin gene. Genetic correction of patient-derived induced pluripotent …

Summary The c-Myc HLH-bZIP protein has been implicated in physiological or pathological
growth, proliferation, apoptosis, metabolism, and differentiation at the cellular, tissue, or …

Recent advances in sequencing technology make it possible to comprehensively catalog
genetic variation in population samples, creating a foundation for understanding human …

The presence of duplicates introduced by PCR amplification is a major issue in paired short
reads from next-generation sequencing platforms. These duplicates might have a serious …

Microalgae are promising feedstock for biofuels yet mechanistic probing of their cellular
network and industrial strain development have been hindered by lack of genome‐editing …

Rapidly evolving sequencing technologies produce data on an unparalleled scale. A central
challenge to the analysis of this data is sequence alignment, whereby sequence reads must …

This article reviews basic concepts, general applications, and the potential impact of next-
generation sequencing (NGS) technologies on genomics, with particular reference to …