Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregation

M Zaman, AN Khan, SM Zakariya, RH Khan - International journal of …, 2019 - Elsevier
Protein and peptides are converted from their soluble forms into highly ordered fibrillar
aggregates under various conditions inside the cell. Such transitions confer diverse …

Elucidating the interaction of limonene with bovine serum albumin: a multi-technique approach

SK Chaturvedi, E Ahmad, JM Khan, P Alam… - Molecular …, 2015 - pubs.rsc.org
The interaction of Bovine Serum Albumin (BSA) with limonene has been studied by UV-
visible spectroscopy, fluorescence spectroscopy and molecular docking, and its effects on …

Formation and pH-stability of whey protein fibrils in the presence of lecithin

RA Mantovani, J Fattori, M Michelon, RL Cunha - Food Hydrocolloids, 2016 - Elsevier
The effect of the soybean lecithin (SL)(0–0.25% w/v) on the kinetics of whey protein (2% w/v)
fibrils formation and their stability under different pH values were evaluated. Linear and long …

The interaction of sodium dodecyl sulfate with trypsin: Multi-spectroscopic analysis, molecular docking, and molecular dynamics simulation

H Ma, T Zou, H Li, H Cheng - International journal of biological …, 2020 - Elsevier
The bioactivity of enzymes is sensitive to certain factors in their application environment,
such as the pH, temperature, ionic strength, and additives, which can alter the native …

Heparin accelerates the protein aggregation via the downhill polymerization mechanism: multi-spectroscopic studies to delineate the implications on proteinopathies

IA Ahanger, ZA Parray, K Nasreen, F Ahmad… - ACS …, 2021 - ACS Publications
Heparin is one of the members of the glycosaminoglycan (GAG) family, which has been
associated with protein aggregation diseases including Alzheimer's disease, Parkinson's …

Selective inhibition of aggregation/fibrillation of bovine serum albumin by osmolytes: Mechanistic and energetics insights

M Dasgupta, N Kishore - PloS one, 2017 - journals.plos.org
Bovine serum albumin (BSA) is an important transport protein of the blood and its
aggregation/fibrillation would adversely affect its transport ability leading to metabolic …

Protonation-State Dependent Modulation of Hen Egg-White Lysozyme Fibrillation under the Influence of a Short Synthetic Peptide

A Mitra, L Naik, R Dhiman, N Sarkar - The Journal of Physical …, 2024 - ACS Publications
Under the influence of various conditions, misfolding of soluble proteins occurs, leading to
the formation of toxic insoluble amyloids. The formation and deposition of such amyloids …

Exploring the mode of binding between food additive “butylated hydroxytoluene (BHT)” and human serum albumin: Spectroscopic as well as molecular docking study

NA Al-Shabib, JM Khan, MS Ali, HA Al-Lohedan… - Journal of Molecular …, 2017 - Elsevier
Butylated hydroxytoluene (BHT) is a food additive and used as an antioxidant in food
products. BHT also concerning several health risks such as cancer, asthma and behavioral …

Negatively charged food additive dye “Allura Red” rapidly induces SDS-soluble amyloid fibril in beta-lactoglobulin protein

NA Al-Shabib, JM Khan, A Malik, AM Alsenaidy… - International journal of …, 2018 - Elsevier
Recent studies have led to an increased interest to categorize small molecular inhibitors of
protein fibrillation. In this study, we used spectroscopy, microscopy and gel electrophoresis …

Evaluation of bishexadecyltrimethyl ammonium palladium tetrachloride based dual functional colloidal carrier as an antimicrobial and anticancer agent

G Kaur, S Kumar, N Dilbaghi, B Kaur, R Kant… - Dalton …, 2016 - pubs.rsc.org
We have developed a dual function carrier using bishexadecyltrimethyl ammonium
palladium tetrachloride, which has anticancer as well as antibacterial activity, using a ligand …