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Blood-based biomarkers for Alzheimer's disease diagnosis and progression: an overview
A Varesi, A Carrara, VG Pires, V Floris, E Pierella… - Cells, 2022 - mdpi.com
Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized by
amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …
amyloid-β (Aβ) plaque deposition and neurofibrillary tangle accumulation in the brain …
Schizophrenia: a disorder of broken brain bioenergetics
ND Henkel, X Wu, SM O'Donovan, EA Devine… - Molecular …, 2022 - nature.com
A substantial and diverse body of literature suggests that the pathophysiology of
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …
The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice
P Zheng, B Zeng, M Liu, J Chen, J Pan, Y Han… - Science …, 2019 - science.org
Schizophrenia (SCZ) is a devastating mental disorder with poorly defined underlying
molecular mechanisms. The gut microbiome can modulate brain function and behaviors …
molecular mechanisms. The gut microbiome can modulate brain function and behaviors …
[HTML][HTML] Metabolomics for the masses: The future of metabolomics in a personalized world
DK Trivedi, KA Hollywood, R Goodacre - New horizons in translational …, 2017 - Elsevier
Current clinical practices focus on a small number of biochemical directly related to the
pathophysiology with patients and thus only describe a very limited metabolome of a patient …
pathophysiology with patients and thus only describe a very limited metabolome of a patient …
Inflammation and the two-hit hypothesis of schizophrenia
KA Feigenson, AW Kusnecov, SM Silverstein - … & Biobehavioral Reviews, 2014 - Elsevier
The high societal and individual cost of schizophrenia necessitates finding better, more
effective treatment, diagnosis, and prevention strategies. One of the obstacles in this …
effective treatment, diagnosis, and prevention strategies. One of the obstacles in this …
A systematic review of metabolite biomarkers of schizophrenia
Current diagnosis of schizophrenia relies exclusively on the potentially subjective
interpretation of clinical symptoms and social functioning as more objective biological …
interpretation of clinical symptoms and social functioning as more objective biological …
Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction
F Guan, T Ni, W Zhu, LK Williams, LB Cui, M Li… - Molecular …, 2022 - nature.com
Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and
complex inheritance. In the past decade, successful identification of numerous susceptibility …
complex inheritance. In the past decade, successful identification of numerous susceptibility …
Assessing the causal effects of human serum metabolites on 5 major psychiatric disorders
J Yang, B Yan, B Zhao, Y Fan, X He, L Yang… - Schizophrenia …, 2020 - academic.oup.com
Psychiatric disorders are the leading cause of disability worldwide while the pathogenesis
remains unclear. Genome-wide association studies (GWASs) have made great …
remains unclear. Genome-wide association studies (GWASs) have made great …
[HTML][HTML] Identification and validation of urinary metabolite biomarkers for major depressive disorder
P Zheng, Y Wang, L Chen, D Yang, H Meng… - Molecular & cellular …, 2013 - Elsevier
Major depressive disorder (MDD) is a widespread and debilitating mental disorder.
However, there are no biomarkers available to aid in the diagnosis of this disorder. In this …
However, there are no biomarkers available to aid in the diagnosis of this disorder. In this …
Impaired membrane lipid homeostasis in schizophrenia
M Li, Y Gao, D Wang, X Hu, J Jiang, Y Qing… - Schizophrenia …, 2022 - academic.oup.com
Abstract Background and Hypothesis Multiple lines of clinical, biochemical, and genetic
evidence suggest that disturbances of membrane lipids and their metabolism are probably …
evidence suggest that disturbances of membrane lipids and their metabolism are probably …