[HTML][HTML] Determinants and outcomes of mitochondrial dynamics
Mitochondria are not only central organelles in metabolism and energy conversion but are
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …
Mitochondrial dynamics at different levels: from cristae dynamics to interorganellar cross talk
AK Kondadi, AS Reichert - Annual Review of Biophysics, 2024 - annualreviews.org
Mitochondria are essential organelles performing important cellular functions ranging from
bioenergetics and metabolism to apoptotic signaling and immune responses. They are …
bioenergetics and metabolism to apoptotic signaling and immune responses. They are …
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA
A Sen, S Kallabis, F Gaedke, C Jüngst, J Boix… - Nature …, 2022 - nature.com
Understanding the mechanisms governing selective turnover of mutation-bearing mtDNA is
fundamental to design therapeutic strategies against mtDNA diseases. Here, we show that …
fundamental to design therapeutic strategies against mtDNA diseases. Here, we show that …
Real-time assessment of mitochondrial DNA heteroplasmy dynamics at the single-cell level
Mitochondrial DNA (mtDNA) is present in multiple copies within cells and is required for
mitochondrial ATP generation. Even within individual cells, mtDNA copies can differ in their …
mitochondrial ATP generation. Even within individual cells, mtDNA copies can differ in their …
In situ architecture of Opa1-dependent mitochondrial cristae remodeling
Cristae membrane state plays a central role in regulating mitochondrial function and cellular
metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists …
metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists …
[HTML][HTML] Collective mitochondrial dynamics resolve conflicting cellular tensions: From plants to general principles
Mitochondria play diverse and essential roles in eukaryotic cells, and plants are no
exception. Plant mitochondria have several differences from their metazoan and fungal …
exception. Plant mitochondria have several differences from their metazoan and fungal …
The mitochondrial citrate carrier SLC25A1 regulates metabolic reprogramming and morphogenesis in the develo** heart
The develo** mammalian heart undergoes an important metabolic shift from glycolysis
towards mitochondrial oxidation that is critical to support the increasing energetic demands …
towards mitochondrial oxidation that is critical to support the increasing energetic demands …
Protein moonlighting by a target gene dominates phenotypic divergence of the Sef1 transcriptional regulatory network in yeasts
Transcriptional rewiring generates phenotypic novelty, acting as an important mechanism
contributing to evolutionary development, speciation, and adaptation in all organisms. The …
contributing to evolutionary development, speciation, and adaptation in all organisms. The …
DarT-mediated mtDNA damage induces dynamic reorganization and selective segregation of mitochondria
Mitochondria are dynamic organelles that play essential roles in cell growth and survival.
Processes of fission and fusion are critical for the distribution, segregation, and maintenance …
Processes of fission and fusion are critical for the distribution, segregation, and maintenance …
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis
Mitochondrial DNA double-strand breaks (mtDSBs) lead to the degradation of circular
genomes and a reduction in copy number; yet, the cellular response in human cells remains …
genomes and a reduction in copy number; yet, the cellular response in human cells remains …