The enzyme iNOS (inducible nitric oxide synthase) generates nitric oxide and is a master
regulator of inflammatory response. 10 We have found that iNOS also has a major …

Peripheral artery disease is a common disorder and a major cause of morbidity and mortality
worldwide. Therapy is directed at reducing the risk of major adverse cardiovascular events …

Simple Summary The crucial immune stimulatory functions exerted by Type I Interferons
(IFNs) in cancer settings have been not only widely demonstrated during the last fifty years …

Direct cellular reprogramming provides a powerful platform to study cell plasticity and
dissect mechanisms underlying cell fate determination. Here, we report a single-cell …

Background: The angiogenic response to ischemia restores perfusion so as to preserve
tissue. A role for mesenchymal-to-endothelial transition in the angiogenic response is …

Outbreaks of influenza, caused by the influenza A virus (IAV), occur almost every year in
various regions worldwide, seriously endangering human health. Studies have shown that …

Epigenetic modification, including histone modification, precisely controls target gene
expression. The posttranscriptional regulation of the innate signaling-triggered production of …

Background: We have previously shown that activation of cell-autonomous innate immune
signaling facilitates the transdifferentiation of fibroblasts into induced endothelial cells, and …

Heroin addiction and withdrawal influence multiple physiological functions, including
immune responses, but the mechanism remains largely elusive. The objective of this study …

Tissue repair requires the orchestration of multiple processes involving a multiplicity of
cellular effectors, signaling pathways, and cell-cell communication. The regeneration of the …