Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the
mammalian host macrophages, involving several environmental changes. The parasite …

Clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR-associated
gene 9 (Cas9) genome editing is set to revolutionize genetic manipulation of pathogens …

Co-infection among leishmaniasis and other infectious diseases is common among natural
populations especially in the endemic areas of the disease. It depends on the environmental …

Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and
potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major …

The protozoan parasite Leishmania possesses a single flagellum, which is remodelled
during the parasite's life cycle from a long motile flagellum in promastigote forms in the sand …

The life cycle of the Leishmania parasite in the sand fly vector involves differentiation into
several distinctive forms, each thought to represent an adaptation to specific …

Protein abundance differs from a few to millions of copies per cell. Trypanosoma brucei
presents an excellent model for studies on codon bias and differential gene expression …

In nearly all eukaryotes, cellular differentiation is governed by changes in transcription, and
stabilized by chromatin and DNA modification. Gene expression control in the pathogen …

Selective transcription of individual protein coding genes does not occur in trypanosomes
and the cellular copy number of each mRNA must be determined post-transcriptionally …

Trypanosomatids are a group of kinetoplastid parasites including some of great public
health importance, causing debilitating and life-long lasting diseases that affect more than …