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MET: a promising anticancer therapeutic target
The MET pathway is dysregulated in many human cancers and promotes tumour growth,
invasion and dissemination. Abnormalities in MET signalling have been reported to …
invasion and dissemination. Abnormalities in MET signalling have been reported to …
Lymphoma dissemination: the other face of lymphocyte homing
ST Pals, DJJ de Gorter… - Blood, The Journal of the …, 2007 - ashpublications.org
The orchestration of systemic immune responses is critically dependent on coordinated
lymphocyte migration and recirculation. This “homing” guides lymphocytes to the …
lymphocyte migration and recirculation. This “homing” guides lymphocytes to the …
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling
The activities of non-haematopoietic cells (NHCs), including mesenchymal stromal cells and
endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our …
endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our …
Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma …
P Amé-Thomas, H Maby-El Hajjami, C Monvoisin… - Blood, 2007 - ashpublications.org
Accumulating evidence indicates that the cellular microenvironment plays a key role in
follicular lymphoma (FL) pathogenesis, both within tumor lymph nodes (LNs) and in …
follicular lymphoma (FL) pathogenesis, both within tumor lymph nodes (LNs) and in …
Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases
GM Coudriet, J He, M Trucco, WM Mars, JD Piganelli - PloS one, 2010 - journals.plos.org
The generation of the pro-inflammatory cytokines IL-6, TNF-α, and IL-1β fuel the acute phase
response (APR). To maintain body homeostasis, the increase of inflammatory proteins is …
response (APR). To maintain body homeostasis, the increase of inflammatory proteins is …
Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas
Primary effusion lymphoma (PEL) constitutes a subset of non-Hodgkin lymphoma whose
incidence is highly increased in the context of HIV infection. Kaposi sarcoma–associated …
incidence is highly increased in the context of HIV infection. Kaposi sarcoma–associated …
[HTML][HTML] New insights into diffuse large B-cell lymphoma pathobiology
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL),
accounting for about 40% of all cases of NHL. Analysis of the tumor microenvironment is an …
accounting for about 40% of all cases of NHL. Analysis of the tumor microenvironment is an …
[HTML][HTML] Mechanisms of hepatocyte growth factor activation in cancer tissues
Hepatocyte growth factor/scatter factor (HGF/SF) plays critical roles in cancer progression
through its specific receptor, MET. HGF/SF is usually synthesized and secreted as an …
through its specific receptor, MET. HGF/SF is usually synthesized and secreted as an …
IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis
Abstract Background Targeting the HGF/MET signaling pathway has been a viable
therapeutic strategy for various cancer types due to hyperactivation of HGF/MET axis occurs …
therapeutic strategy for various cancer types due to hyperactivation of HGF/MET axis occurs …
FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells
M van Keimpema, LJ Grüneberg… - Blood, The Journal …, 2014 - ashpublications.org
The forkhead transcription factor FOXP1 is involved in B-cell development and function and
is generally regarded as an oncogene in activated B-cell–like subtype of diffuse large B-cell …
is generally regarded as an oncogene in activated B-cell–like subtype of diffuse large B-cell …