Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …

Estrogens have historically been associated with female reproduction, but work over the last
two decades established that estrogens and their main nuclear receptors (ESR1 and ESR2) …

Background The androgen receptor (AR) is the classical target for prostate cancer
prevention and treatment, but more recently estrogens and their receptors have also been …

Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain
receptor that mediates non-genomic estrogen related signaling. After ligand activation …

G protein-coupled estrogen receptor 1 (GPER1), is a functional estrogen receptor involved
in estrogen related actions on several systems including processes of the nervous …

Estrogens play important roles in the development and progression of multiple tumor types.
Accumulating evidence points to the significance of estrogen action not only in tumors of …

Prostate cancer is one of the most commonly diagnosed cancers in men, and androgen
deprivation therapy still represents the primary treatment for prostate cancer patients. This …

Many environmental chemicals have been found to exert estrogenic effects in cells and
experimental animals by activating nuclear receptors such as estrogen receptors and …