A brief introduction to chemical reaction optimization

CJ Taylor, A Pomberger, KC Felton, R Grainger… - Chemical …, 2023‏ - ACS Publications
From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …

An overview of process systems engineering approaches for process intensification: State of the art

Y Tian, SE Demirel, MMF Hasan… - … and Processing-Process …, 2018‏ - Elsevier
Process intensification offers the potential to drastically reduce the energy consumption and
cost of producing chemicals from both bulk and distributed feedstocks. This review article …

The past, present and potential for microfluidic reactor technology in chemical synthesis

KS Elvira, XC i Solvas, RCR Wootton, AJ Demello - Nature chemistry, 2013‏ - nature.com
The past two decades have seen far-reaching progress in the development of microfluidic
systems for use in the chemical and biological sciences. Here we assess the utility of …

Towards the standardization of flow chemistry protocols for organic reactions

CA Hone, CO Kappe - Chemistry‐Methods, 2021‏ - Wiley Online Library
Flow chemistry studies can sometimes be difficult to reproduce. In this article we provide
guidance to scientists for experimental details that should be considered as part of any …

Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis

RL Hartman, JP McMullen… - Angewandte Chemie …, 2011‏ - Wiley Online Library
The fine chemicals and pharmaceutical industries are transforming how their products are
manufactured, where economically favorable, from traditional batchwise processes to …

Toxicity of ionic liquids: eco (cyto) activity as complicated, but unavoidable parameter for task‐specific optimization

KS Egorova, VP Ananikov - ChemSusChem, 2014‏ - Wiley Online Library
Rapid progress in the field of ionic liquids in recent decades led to the development of many
outstanding energy‐conversion processes, catalytic systems, synthetic procedures, and …

Lab-on-a-chip: microfluidics in drug discovery

PS Dittrich, A Manz - Nature reviews Drug discovery, 2006‏ - nature.com
Miniaturization can expand the capability of existing bioassays, separation technologies and
chemical synthesis techniques. Although a reduction in size to the micrometre scale will …

Micromixers—a review on passive and active mixing principles

V Hessel, H Löwe, F Schönfeld - Chemical engineering science, 2005‏ - Elsevier
A review on microstructured mixer devices and their mixing principles concerning miscible
liquids (and gases) is given. This is supplemented by the description of typical mixing …

Control and detection of chemical reactions in microfluidic systems

AJ Demello - Nature, 2006‏ - nature.com
Recent years have seen considerable progress in the development of microfabricated
systems for use in the chemical and biological sciences. Much development has been …

Microchemical systems for continuous-flow synthesis

RL Hartman, KF Jensen - Lab on a Chip, 2009‏ - pubs.rsc.org
Microchemical systems have evolved rapidly over the last decade with extensive chemistry
applications. Such systems enable discovery and development of synthetic routes while …