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The blood–brain barrier in systemic infection and inflammation
I Galea - Cellular & molecular immunology, 2021 - nature.com
The vascular blood–brain barrier is a highly regulated interface between the blood and
brain. Its primary function is to protect central neurons while signaling the presence of …
brain. Its primary function is to protect central neurons while signaling the presence of …
Predisposing and precipitating factors associated with delirium: a systematic review
Importance Despite discrete etiologies leading to delirium, it is treated as a common end
point in hospital and in clinical trials, and delirium research may be hampered by the attempt …
point in hospital and in clinical trials, and delirium research may be hampered by the attempt …
Neuroinflammation and perioperative neurocognitive disorders
S Subramaniyan, N Terrando - Anesthesia & Analgesia, 2019 - journals.lww.com
Neuroinflammation has become a key hallmark of neurological complications including
perioperative pathologies such as postoperative delirium and longer-lasting postoperative …
perioperative pathologies such as postoperative delirium and longer-lasting postoperative …
[HTML][HTML] The blood-brain barrier in systemic inflammation
A Varatharaj, I Galea - Brain, behavior, and immunity, 2017 - Elsevier
The blood-brain barrier (BBB) plays a key role in maintaining the specialized
microenvironment of the central nervous system (CNS), and enabling communication with …
microenvironment of the central nervous system (CNS), and enabling communication with …
Pharmacokinetic alterations associated with critical illness
D Morales Castro, L Dresser, J Granton, E Fan - Clinical Pharmacokinetics, 2023 - Springer
Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect
drug pharmacokinetics and pharmacodynamics making dose optimisation particularly …
drug pharmacokinetics and pharmacodynamics making dose optimisation particularly …
[HTML][HTML] Postoperative delirium and changes in the blood–brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study
Background Case-control studies have associated delirium with blood–brain barrier (BBB)
permeability. However, this approach cannot determine whether delirium is attributable to …
permeability. However, this approach cannot determine whether delirium is attributable to …
Acute brain failure: pathophysiology, diagnosis, management, and sequelae of delirium
JR Maldonado - Critical care clinics, 2017 - criticalcare.theclinics.com
Delirium is the most common neuropsychiatric syndrome found in the acute care setting,
with a prevalence ranging from 10% in general medicine to 85% in advanced cancer and …
with a prevalence ranging from 10% in general medicine to 85% in advanced cancer and …
Neuroinflammation after surgery: from mechanisms to therapeutic targets
T Yang, R Velagapudi, N Terrando - Nature immunology, 2020 - nature.com
Injury is a key driver of inflammation, a critical yet necessary response involving several
mediators that is aimed at restoring tissue homeostasis. Inflammation in the central nervous …
mediators that is aimed at restoring tissue homeostasis. Inflammation in the central nervous …
Intensive care unit delirium: a review of diagnosis, prevention, and treatment
CJ Hayhurst, PP Pandharipande… - Anesthesiology, 2016 - pmc.ncbi.nlm.nih.gov
A 77 year-old male is admitted to the hospital after sustaining a hip fracture. He has a past
medical history of chronic obstructive pulmonary disease, hypertension, hyperlipidemia …
medical history of chronic obstructive pulmonary disease, hypertension, hyperlipidemia …
Long-term cognitive and functional impairments after critical illness
KF Rengel, CJ Hayhurst, PP Pandharipande… - Anesthesia & …, 2019 - journals.lww.com
As critical illness survivorship increases, patients and health care providers are faced with
management of long-term sequelae including cognitive and functional impairment …
management of long-term sequelae including cognitive and functional impairment …