microRNAs biogenesis, functions and role in tumor angiogenesis

T Annese, R Tamma, M De Giorgis, D Ribatti - Frontiers in oncology, 2020 - frontiersin.org
microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …

[HTML][HTML] Roles for microRNAs in conferring robustness to biological processes

MS Ebert, PA Sharp - Cell, 2012 - cell.com
Biological systems use a variety of mechanisms to maintain their functions in the face of
environmental and genetic perturbations. Increasing evidence suggests that, among their …

[HTML][HTML] Joint masking and self-supervised strategies for inferring small molecule-miRNA associations

Z Zhou, L Zhuo, X Fu, J Lv, Q Zou, R Qi - Molecular Therapy-Nucleic Acids, 2024 - cell.com
Inferring small molecule-miRNA associations (MMAs) is crucial for revealing the intricacies
of biological processes and disease mechanisms. Deep learning, renowned for its …

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

L Zhang, D Hou, X Chen, D Li, L Zhu, Y Zhang, J Li… - Cell research, 2012 - nature.com
Our previous studies have demonstrated that stable microRNAs (miRNAs) in mammalian
serum and plasma are actively secreted from tissues and cells and can serve as a novel …

[HTML][HTML] miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury

Z Wei, S Qiao, J Zhao, Y Liu, Q Li, Z Wei, Q Dai, L Kang… - Life sciences, 2019 - Elsevier
Aims The inflammation modulation effects of mesenchymal stromal cell-derived exosomes
(MSC-EXO) are well established. We aimed to explore the mechanism behind the …

Intracellular and extracellular microRNA: An update on localization and biological role

JA Makarova, MU Shkurnikov, D Wicklein… - … in histochemistry and …, 2016 - Elsevier
MicroRNA (miRNA) is a class of small non-coding RNAs which mediate post-transcriptional
gene silencing (PTGS) by sequence-specific inhibition of target mRNAs translation and/or …

MicroRNAs in cancer

R Garzon, GA Calin, CM Croce - Annual review of medicine, 2009 - annualreviews.org
MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development,
cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is …

MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

MS Ebert, JR Neilson, PA Sharp - Nature methods, 2007 - nature.com
MicroRNAs are predicted to regulate thousands of mammalian genes, but relatively few
targets have been experimentally validated and few microRNA loss-of-function phenotypes …

The evolution of gene regulation by transcription factors and microRNAs

K Chen, N Rajewsky - Nature Reviews Genetics, 2007 - nature.com
Abstract Changes in the patterns of gene expression are widely believed to underlie many of
the phenotypic differences within and between species. Although much emphasis has been …

Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma

IA Babar, CJ Cheng, CJ Booth, X Liang… - Proceedings of the …, 2012 - pnas.org
MicroRNA-155 (miR-155) is an oncogenic microRNA that regulates several pathways
involved in cell division and immunoregulation. It is overexpressed in numerous cancers, is …