The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a
genetically identical group are the same. This heterogeneity at the single-cell level has been …

Single-cell manipulation and analysis is critical to the study of many fundamental biological
processes and uncovering cellular heterogeneity, and presents the potential for extremely …

Microfluidic technologies offer a number of advantages for sample preparation in point-of-
care testing (POCT), but the requirement for complicated external pum** systems limits …

Microrobots have been developed for applications in the submillimeter domain such as the
manipulation of micro-objects and microsurgery. Rapid progress has been achieved in …

Understanding molecular, cellular, genetic and functional heterogeneity of tumors at the
single-cell level has become a major challenge for cancer research. The microfluidic …

The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor
microemboli, in biological fluids has long been described. Intensive research on single …

Circulating tumor cell (CTC) clusters that are shed from the primary tumor into the
bloodstream are associated with a poor prognosis, elevated metastatic potential, higher …

Microfluidic devices have been widely applied to trap** and isolation of cells and clusters
for controllable intercellular environments and high-throughput analysis, triggering …

Recent advances in single-cell analysis have unraveled substantial heterogeneity among
seemingly identical cells at genomic and transcriptomic levels. These discoveries have …