The significant parallels between cell plasticity during embryonic development and
carcinoma progression have helped us understand the importance of the epithelial …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid malignancies
and is characterized by its insensitivity to current therapy. The invasion and metastasis of …

Background & Aims Little is known about how the immune system affects stem cell features
of pancreatic cancer cells. Immune cells that produce interleukin 17A (IL17A) in the …

Cell activity is coordinated by dynamic interactions with the extracellular matrix, often
through stimuli‐mediated spatiotemporal stiffening and softening. Dynamic changes in …

Derived from any somatic cell type and possessing unlimited self‐renewal and
differentiation potential, induced pluripotent stem cells (iPSC s) are poised to revolutionize …

Krüppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription
factors, that are involved in a plethora of cellular processes, ranging from proliferation and …

The discovery of induced pluripotent stem cells (iPSCs), reprogrammed to pluripotency from
somatic cells, has transformed the landscape of regenerative medicine, disease modelling …

Introduction: The plasticity of cell identity allows cellular reprogramming that manipulates the
lineage of cells to generate the target cell types, bringing new avenues for disease modeling …

The proper functioning of multicellular organisms requires the robust establishment of
precise proportions between distinct cell types. This developmental differentiation process …

Regenerative medicine entails regenerating damaged cells and tissues from healthy cells
through the process of cellular reprogramming. The most common method to achieve …