The κ-opioid receptor (KOR) has recently emerged as an alternative therapeutic target for
the development of pain medications, without deleterious side effects associated with the μ …

Kappa opioid receptor (KOR) agonists produce analgesic and anti-pruritic effects, but their
clinical application was limited by dysphoria and hallucinations. Nalfurafine, a clinically used …

Background and purpose The κ receptor has a central role in modulating neurotransmission
in central and peripheral neuronal circuits that subserve pain and other behavioural …

Kappa opioid receptor (KOPr) agonists represent alternative analgesics for their low abuse
potential, although relevant adverse effects have limited their clinical use. Functionally …

Among the opioid receptors, the kappa opioid receptor (KOR) has been gaining substantial
attention as a promising molecular target for the treatment of numerous human disorders …

Repeated stress releases dynorphins and causes subsequent activation of κ-opioid
receptors (KORs) in limbic brain regions. The serotonergic dorsal raphe nucleus (DRN) has …

Here we report on the design, synthesis, and biological characterization of novel κ opioid
(KOP) receptor ligands of diphenethylamines. In opioid receptor binding and functional …

We previously reported on a series of small molecules targeting the κ-opioid (KOP) receptor
featuring a diphenethylamine scaffold and showed the promise of these ligands as effective …

Kappa-opioid receptor (KOR) antagonists are promising innovative therapeutics for the
treatment of the central nervous system (CNS) disorders. The new scaffold opioid ligand …

Recently, the fungus secondary metabolite cyclotetrapetide c [Trp-Phe-D-Pro-Phe](CJ-
15,208) and its derivatives deserved some attention for their unusual structure and …