Chemically fueled self‐assembly in biology and chemistry
Life is a non‐equilibrium state of matter maintained at the expense of energy. Nature uses
predominantly chemical energy stored in thermodynamically activated, but kinetically stable …
predominantly chemical energy stored in thermodynamically activated, but kinetically stable …
[HTML][HTML] Striatal dopamine neurotransmission: regulation of release and uptake
Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …
Structure and dynamics of the M3 muscarinic acetylcholine receptor
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological
actions via activation of a family of G-protein-coupled receptors (GPCRs) known as …
actions via activation of a family of G-protein-coupled receptors (GPCRs) known as …
The neurobiology and control of anxious states
MJ Millan - Progress in neurobiology, 2003 - Elsevier
Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
(external and internal) stimuli which threaten to perturb homeostasis. However, when …
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Muscarinic acetylcholine receptors (mAChRs), M1–M5, regulate the activity of numerous
fundamental central and peripheral functions. The lack of small-molecule ligands that can …
fundamental central and peripheral functions. The lack of small-molecule ligands that can …
Discovery and development of tramadol for the treatment of pain
Introduction: Tramadol is an opioid drug that, unlike classic opioids, also modulates the
monoaminergic system by inhibiting noradrenergic and serotoninergic reuptake. For this …
monoaminergic system by inhibiting noradrenergic and serotoninergic reuptake. For this …
Striatal cholinergic interneuron regulation and circuit effects
The striatum plays a central role in motor control and motor learning. Appropriate responses
to environmental stimuli, including pursuit of reward or avoidance of aversive experience all …
to environmental stimuli, including pursuit of reward or avoidance of aversive experience all …
Muscle and neuronal nicotinic acetylcholine receptors: structure, function and pathogenicity
D Kalamida, K Poulas, V Avramopoulou… - The FEBS …, 2007 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …
Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice
SE Hamilton, MD Loose, M Qi… - Proceedings of the …, 1997 - National Acad Sciences
Muscarinic acetylcholine receptors are members of the G protein-coupled receptor
superfamily expressed in neurons, cardiomyocytes, smooth muscle, and a variety of …
superfamily expressed in neurons, cardiomyocytes, smooth muscle, and a variety of …
The cellular model for Alzheimer's disease research: PC12 cells
D **e, T Deng, Z Zhai, T Sun, Y Xu - Frontiers in Molecular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive decline and irreversible memory impairment …
characterized by progressive cognitive decline and irreversible memory impairment …