Importance Stroke is the fifth leading cause of death and a leading cause of disability in the
United States, affecting nearly 800 000 individuals annually. Observations Sudden …

Stroke is the second leading cause of death and a major cause of disability worldwide. Its
incidence is increasing because the population ages. In addition, more young people are …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Atherosclerosis is a leading cause of vascular disease worldwide. Its major clinical
manifestations include ischemic heart disease, ischemic stroke, and peripheral arterial …

The presence of a patent foramen ovale (PFO) is implicated in the pathogenesis of a number
of medical conditions; however, the subject remains controversial and no official statements …

Cardiac embolism accounts for an increasing proportion of ischemic strokes and might
multiply several-fold during the next decades. However, research points to several potential …

Two decades of epidemiological research shows that silent cerebrovascular disease is
common and is associated with future risk for stroke and dementia. It is the most common …

Over the past few decades, mortality due to cerebrovascular disease has decreased, likely
due to earlier diagnosis and aggressive management of vascular risk factors with lifestyle …

Ischaemic strokes have traditionally been classified according to the TOAST criteria, in
which strokes with unclear aetiology are classified as cryptogenic strokes. However, the …

Background A third of transient ischaemic attacks (TIAs) and ischaemic strokes are of
undetermined cause (ie, cryptogenic), potentially undermining secondary prevention. If …