Human pluripotent stem cell (hPSC)-derived neuron cultures have emerged as models of
electrical activity in the human brain. Microelectrode arrays (MEAs) measure changes in the …

Neuron interface devices can be used to explore the relationships between neuron firing
and synaptic transmission, as well as to diagnose and treat neurological disorders, such as …

Interictal epileptiform discharges (IEDs), also known as interictal spikes, are large
intermittent electrophysiological events observed between seizures in patients with epilepsy …

Accurate anatomical localization of intracranial electrodes is important for identifying the
seizure foci in patients with epilepsy and for interpreting effects from cognitive studies …

Neurological disorders such as epilepsy arise from disrupted brain networks. Our capacity to
treat these disorders is limited by our inability to map these networks at sufficient temporal …

Objective Stereotactic laser amygdalohippocampotomy (SLAH) is an appealing option for
patients with temporal lobe epilepsy, who often require intracranial monitoring to confirm …

The relationship between clinically accessible epileptic biomarkers and neuronal activity
underlying the transition to seizure is complex, potentially leading to imprecise delineation of …

Loss of consciousness is a hallmark of many epileptic seizures and carries risks of serious
injury and sudden death. While cortical sleep-like activities accompany loss of …

Understanding the neuronal basis of epileptic activity is a major challenge in neurology.
Cellular integration into larger scale networks is all the more challenging. In the local field …

Learning algorithms based on synchronization of oscillators are currently being pursued as
an alternative to standard neural-network algorithms for data classification. For such …