Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

Introduction Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have
been crucial in advancing the understanding of Alzheimer's disease (AD) pathophysiology …

Brain imaging genomics is an emerging data science field, where integrated analysis of
brain imaging and genomics data, often combined with other biomarker, clinical, and …

DNA methylation differences in Alzheimer's disease (AD) have been reported. Here, we
conducted a meta-analysis of more than 1000 prefrontal cortex brain samples to prioritize …

Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

Brain amyloid deposition is thought to be a seminal event in Alzheimer's disease. To identify
genes influencing Alzheimer's disease pathogenesis, we performed a genome-wide …

Diagnosing primary mitochondrial diseases is challenging in clinical practice. Although,
defective oxidative phosphorylation (OXPHOS) is the common final pathway, it is unknown …

Pre-trained large language models (LLMs) have attracted increasing attention in biomedical
domains due to their success in natural language processing. However, the complex traits …

Involvement of life stress in Late-Onset Alzheimer's Disease (LOAD) has been evinced in
longitudinal cohort epidemiological studies, and endocrinologic evidence suggests …