FUNDC1 alleviates doxorubicin-induced cardiotoxicity by restoring mitochondrial-endoplasmic reticulum contacts and blocked autophagic flux
W He, Z Sun, G Tong, L Zeng, W He, X Chen… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Autophagy dysregulation is known to be a mechanism of doxorubicin (DOX)-
induced cardiotoxicity (DIC). Mitochondrial-Endoplasmic Reticulum Contacts (MERCs) are …
induced cardiotoxicity (DIC). Mitochondrial-Endoplasmic Reticulum Contacts (MERCs) are …
Understanding the molecular regulatory mechanisms of autophagy in lung disease pathogenesis
L Lin, Y Lin, Z Han, K Wang, S Zhou, Z Wang… - Frontiers in …, 2024 - frontiersin.org
Lung disease development involves multiple cellular processes, including inflammation, cell
death, and proliferation. Research increasingly indicates that autophagy and its regulatory …
death, and proliferation. Research increasingly indicates that autophagy and its regulatory …
Spermidine Recovers the Autophagy Defects Underlying the Pathophysiology of Cell Trafficking Disorders
Y Díaz‐Osorio, H Gimeno‐Agud… - Journal of Inherited …, 2025 - Wiley Online Library
Cell trafficking alterations are a growing group of disorders and one of the largest categories
of Inherited Metabolic Diseases. They have complex and variable clinical presentation …
of Inherited Metabolic Diseases. They have complex and variable clinical presentation …
Sodium Orthovanadate Mitigates Nonalcoholic Fatty Liver Disease by Enhancing Autophagy
X Zhang, H Zhou, Z Kong, T Li, C Zhu… - Biological and …, 2024 - jstage.jst.go.jp
Sodium orthovanadate (SOV) has been investigated in recent research for its therapeutic
efficacy in treating metabolic disorders. Considering the rising prevalence of non-alcoholic …
efficacy in treating metabolic disorders. Considering the rising prevalence of non-alcoholic …