The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

Yttrium‐90 transarterial radioembolization (TARE) is a locoregional therapy (LRT) for
hepatocellular carcinoma (HCC). In this study, we present overall survival (OS) outcomes in …

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

The lifespan of an organism is strongly influenced by environmental factors (including diet)
and by internal factors (notably reproductive status). Lipid metabolism is critical for …

Insulin-induced gene (Insig) negatively regulates SREBP-mediated de novo fatty acid
synthesis in the liver. However, the upstream regulation of Insig is incompletely understood …

Glucocorticoids (GCs) are a class of steroid hormones that regulate key physiological
processes such as metabolism, immune function, and stress responses. The effects of GCs …

Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to
cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non …

Depression is a mental illness frequently accompanied by disordered energy metabolism. A
dysregulated hypothalamus pituitary adrenal axis response with aberrant glucocorticoids …