Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Proper development and function of the mammalian central nervous system (CNS) depend
critically on the activity of parenchymal sentinels referred to as microglia. Although microglia …

Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …

Abstract (R, S)-ketamine elicits rapid-acting and sustained antidepressant actions in
treatment-resistant patients with depression.(R)-ketamine produces longer-lasting …

Mutations in the methyl-DNA-binding protein MECP2 cause the neurodevelopmental
disorder Rett syndrome (RTT). How MECP2 contributes to transcriptional regulation in …

Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …

Abstract Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive
heterochromatin, which is crucial for chromosome maintenance and transcriptional …

Although DNA methylation was originally thought to only affect transcription, emerging
evidence shows that it also regulates alternative splicing. Exons, and especially splice sites …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

DNA methylation is a critical component of gene regulation and plays an important role in
the development of cancer. Hypermethylation of tumor suppressor genes and silencing of …