Therapeutic advances in multiple sclerosis

JH Yang, T Rempe, N Whitmire, A Dunn-Pirio… - Frontiers in …, 2022 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system that
causes significant disability and healthcare burden. The treatment of MS has evolved over …

Immunological aspects of approved MS therapeutics

PS Rommer, R Milo, MH Han, S Satyanarayan… - Frontiers in …, 2019 - frontiersin.org
Multiple sclerosis (MS) is the most common neurological immune-mediated disease leading
to disability in young adults. The outcome of the disease is unpredictable, and over time …

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis

X Montalban, R Gold, AJ Thompson… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming
available in the past years. There is a need for a reference tool compiling current data to aid …

Silent progression in disease activity–free relapsing multiple sclerosis

University of California, San Francisco MS … - Annals of …, 2019 - Wiley Online Library
Objective Rates of worsening and evolution to secondary progressive multiple sclerosis
(MS) may be substantially lower in actively treated patients compared to natural history …

Teriflunomide and time to clinical multiple sclerosis in patients with radiologically isolated syndrome: the TERIS randomized clinical trial

C Lebrun-Frénay, A Siva, MP Sormani… - JAMA …, 2023 - jamanetwork.com
Importance Radiologically isolated syndrome (RIS) represents the earliest detectable
preclinical phase of multiple sclerosis (MS) punctuated by incidental magnetic resonance …

The disease-modifying therapies of relapsing-remitting multiple sclerosis and liver injury: a narrative review

M Biolato, A Bianco, M Lucchini, A Gasbarrini… - CNS drugs, 2021 - Springer
In this narrative review, we analyze pre-registration and post-marketing data concerning
hepatotoxicity of all disease-modifying therapies (DMTs) available for the treatment of …

Early use of high-efficacy therapies in multiple sclerosis in the United States: benefits, barriers, and strategies for encouraging adoption

BA Singer, J Feng, H Chiong-Rivero - Journal of Neurology, 2024 - Springer
Multiple sclerosis (MS) is characterized by progressive neuroinflammation and
neurodegeneration from disease onset that, if left untreated, can result in the accumulation …

Safety and efficacy of teriflunomide in paediatric multiple sclerosis (TERIKIDS): a multicentre, double-blind, phase 3, randomised, placebo-controlled trial

T Chitnis, B Banwell, L Kappos, DL Arnold… - The Lancet …, 2021 - thelancet.com
Background Therapeutic options for children with multiple sclerosis are scarce.
Teriflunomide is approved in more than 80 countries for the treatment of adults with …

Infections in patients receiving multiple sclerosis disease-modifying therapies

E Grebenciucova, A Pruitt - Current neurology and neuroscience reports, 2017 - Springer
Abstract Purpose of Review This paper will systemically review the risk of infections
associated with current disease-modifying treatments and will discuss pre-treatment testing …

Efficacy and safety of the newer multiple sclerosis drugs approved since 2010

S Faissner, R Gold - CNS drugs, 2018 - Springer
Multiple sclerosis treatment faces tremendous changes as a result of the approval of new
medications. The new medications have differing safety considerations and risks after long …