Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - Signal transduction and …, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

[HTML][HTML] Beyond the GFAP-astrocyte protein markers in the brain

AM Jurga, M Paleczna, J Kadluczka, KZ Kuter - Biomolecules, 2021 - mdpi.com
The idea of central nervous system as one-man band favoring neurons is long gone. Now
we all are aware that neurons and neuroglia are team players and constant communication …

Microglia-astrocyte crosstalk: an intimate molecular conversation

MK Jha, M Jo, JH Kim, K Suk - The Neuroscientist, 2019 - journals.sagepub.com
Microglia-astrocyte crosstalk has recently been at the forefront of glial research. Emerging
evidence illustrates that microglia-and astrocyte-derived signals are the functional …

Glial responses to implanted electrodes in the brain

JW Salatino, KA Ludwig, TDY Kozai… - Nature biomedical …, 2017 - nature.com
The use of implants that can electrically stimulate or record electrophysiological or
neurochemical activity in nervous tissue is rapidly expanding. Despite remarkable results in …

Astrocytes: a central element in neurological diseases

M Pekny, M Pekna, A Messing, C Steinhäuser… - Acta …, 2016 - Springer
The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …

Astrocyte metabolism and signaling pathways in the CNS

Y Zhang, Y Qi, Y Gao, W Chen, T Zhou… - Frontiers in …, 2023 - frontiersin.org
Astrocytes comprise half of the cells in the central nervous system and play a critical role in
maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated …

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

L Hösli, N Binini, KD Ferrari, L Thieren, ZJ Looser… - Cell reports, 2022 - cell.com
The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and
memory are still poorly explored. Astrocytes form large intercellular networks by gap junction …

[HTML][HTML] Direct vascular contact is a hallmark of cerebral astrocytes

L Hösli, M Zuend, G Bredell, HS Zanker… - Cell reports, 2022 - cell.com
Astrocytes establish extensive networks via gap junctions that allow each astrocyte to
connect indirectly to the vasculature. However, the proportion of astrocytes directly …

The role of astrocyte‐mediated plasticity in neural circuit development and function

NA Perez-Catalan, CQ Doe, SD Ackerman - Neural development, 2021 - Springer
Neuronal networks are capable of undergoing rapid structural and functional changes called
plasticity, which are essential for sha** circuit function during nervous system …

[HTML][HTML] Astrocyte-neuron circuits in epilepsy

BS Purnell, M Alves, D Boison - Neurobiology of disease, 2023 - Elsevier
The epilepsies are a diverse spectrum of disease states characterized by spontaneous
seizures and associated comorbidities. Neuron-focused perspectives have yielded an array …