Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Multi-cellular organisms such as humans contain hundreds of cell types that share the same
genetic information (DNA sequences), and yet have different cellular traits and functions …

The inheritance of parental histones across the replication fork is thought to mediate
epigenetic memory. Here, we reveal that fission yeast Mrc1 (CLASPIN in humans) binds H3 …

Polycomb repressive complexes 1 and 2 (PRC1 and 2) are required for heritable repression
of developmental genes. The cis-and trans-acting factors that contribute to epigenetic …

Faithful transfer of parental histones to newly replicated daughter DNA strands is critical for
inheritance of epigenetic states. Although replication proteins that facilitate parental histone …

In eukaryotes, the Suv39 family of proteins tri-methylate lysine 9 of histone H3 (H3K9me) to
form constitutive heterochromatin. However, how Suv39 proteins are nucleated at …

Stable transmission of non-DNA-sequence-based epigenetic information contributes to
heritable phenotypic variants and thus to biological diversity. While studies on spontaneous …

Schizosaccharomyces pombe is an ascomycete fungus that divides by medial fission; it is
thus commonly referred to as fission yeast, as opposed to the distantly related budding yeast …

Heterochromatic loci can exhibit different transcriptional states in genetically identical cells.
A popular model posits that the inheritance of modified histones is sufficient for inheritance …

In this article I review mechanisms that underpin epigenetic inheritance of CpG methylation
and histone H3 lysine 9 methylation (H3K9me) in chromatin in fungi and mammals. CpG …