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Acute hypoxic respiratory failure (AHRF) is a prominent feature of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) critical illness. The severity of gas exchange …

Background The safety of perioperative hyperoxia is currently unclear. Previous studies in
patients undergoing coronary artery bypass surgery suggest reduced myocardial damage …

Background Normobaric hyperoxia is used to alleviate secondary brain ischaemia in
patients with traumatic brain injury (TBI), but clinical evidence is limited and hyperoxia may …

Purpose The relationship between arterial hyperoxia exposure and clinical outcome is
under increasing scrutiny. We therefore performed an update meta-analysis to evaluate the …

Oxygen is both lifesaving and toxic. Appropriate use of oxygen aims to provide a balance
between the two effects. Although local oxygen toxicity to the lung is well accepted, recent …

Background The interest in perioperative lung protective ventilation has been increasing.
However, optimal management during one-lung ventilation (OLV) remains undetermined …

Oxygen is the most commonly used drug in critical care. However, because it is a gas, most
clinicians and most patients do not regard it as a drug. For this reason, the use of medical …

BACKGROUND: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is used
when mechanical ventilation can no longer support oxygenation or ventilation, or if the risk …

Background Supplemental oxygen therapy is commonly required for respiratory failure
requiring mechanical ventilation in the ICU. However, hyperoxaemia may be injurious and …