Propargylamines are a versatile class of compounds which find broad application in many
fields of chemistry. This review aims to describe the different strategies developed so far for …

Click chemistry is a set of easy, atom-economical reactions that are often utilized to combine
two desired chemical entities. Click chemistry accelerates lead identification and …

Monoamine oxidase (MAO) inhibitors have made significant contributions and remain an
indispensable approach of molecular and mechanistic diversity for the discovery of …

Alzheimer's disease is a most prevalent form of dementia all around the globe and currently
poses a significant challenge to the healthcare system. Currently available drugs only slow …

Alzheimer's disease (AD) is a multi-factorial disease, which can be simply outlined as an
irreversible and progressive neurodegenerative disorder with an unclear root cause. It is a …

Current options for the treatment of Alzheimeŕs disease have been restricted to prescription
of acetylcholinesterase inhibitors or N-methyl-d-aspartate receptor antagonist, memantine …

Monoamine oxidases (MAOs) and vascular endothelial growth factor receptor-2 (VEGFR-2)
are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial …

A series of coumarin-pargyline hybrids (4a-x) have been designed, synthesized and
evaluated as novel dual inhibitors of Alzheimer's disease (AD). Most of the compounds …

Abstract Monoamine oxidase (EC 1.4. 3.4, MAO) is a flavin adenine dinucleotide-containing
flavoenzyme located on the outer mitochondrial membrane and catalyzes the oxidative …

Xanthine derivatives have been a great area of interest for the development of potent
bioactive agents. Thirty-eight methylxanthine derivatives as acetylcholinesterase inhibitors …