Association between completed suicide and bipolar disorder: A systematic review of the literature

L Plans, C Barrot, E Nieto, J Rios, TG Schulze… - Journal of affective …, 2019 - Elsevier
Background Completed suicide is a major cause of death in bipolar disorder (BD) patients.
Objective The aim of this paper is to provide an overall review of the existing literature of …

An excitatory synapse hypothesis of depression

SM Thompson, AJ Kallarackal, MD Kvarta… - Trends in …, 2015 - cell.com
Depression is a common cause of mortality and morbidity, but the biological bases of the
deficits in emotional and cognitive processing remain incompletely understood. Current …

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy

M Notaras, R Hill, M van den Buuse - Molecular psychiatry, 2015 - nature.com
Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development,
differentiation and plasticity in both the develo** and adult brain. A single-nucleotide …

Critical Issues in BDNF Val66Met Genetic Studies of Neuropsychiatric Disorders

SJ Tsai - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Neurotrophins have been implicated in the pathophysiology of many neuropsychiatric
diseases. Brain-derived neurotrophic factor (BDNF) is the most abundant and widely …

Stress and trauma: BDNF control of dendritic-spine formation and regression

MR Bennett, J Lagopoulos - Progress in neurobiology, 2014 - Elsevier
Chronic restraint stress leads to increases in brain derived neurotrophic factor (BDNF)
mRNA and protein in some regions of the brain, eg the basal lateral amygdala (BLA) but …

BDNF promoter methylation and suicidal behavior in depressive patients

HJ Kang, JM Kim, JY Lee, SY Kim, KY Bae… - Journal of affective …, 2013 - Elsevier
Introduction Suicide is a major health problem, and depression is a major psychiatric cause
of suicide. Suicide is influenced by the multifactorial interaction of many risk factors …

Genetic association studies of suicidal behavior: a review of the past 10 years, progress, limitations, and future directions

B Mirkovic, C Laurent, MA Podlipski, T Frebourg… - Frontiers in …, 2016 - frontiersin.org
Suicidal behaviors (SBs), which range from suicidal ideation to suicide attempts and
completed suicide, represent a fatal dimension of mental ill-health. The involvement of …

Gene environment interaction studies in depression and suicidal behavior: an update

L Mandelli, A Serretti - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
Increasing evidence supports the involvement of both heritable and environmental risk
factors in major depression (MD) and suicidal behavior (SB). Studies investigating gene …

Understanding suicide risk within the Research Domain Criteria (RDoC) framework: Insights, challenges, and future research considerations

CR Glenn, CB Cha, EM Kleiman… - Clinical psychological …, 2017 - journals.sagepub.com
Suicide is a leading cause of death worldwide. Prior research has focused primarily on
sociodemographic and psychiatric risk factors with little improvement in the prediction or …

Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome‐wide association and polygenic scoring study

N Mullins, N Perroud, R Uher, AW Butler… - American Journal of …, 2014 - Wiley Online Library
Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is
independent of other psychiatric disorders. Genome‐wide association studies (GWAS) on …