[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

COVID-19: Current understanding of its Pathophysiology, Clinical presentation and Treatment

A Parasher - Postgraduate medical journal, 2021 - academic.oup.com
Background The severe acute respiratory syndrome (SARS) coronavirus-2 is a novel
coronavirus belonging to the family Coronaviridae and is now known to be responsible for …

Early remdesivir to prevent progression to severe Covid-19 in outpatients

RL Gottlieb, CE Vaca, R Paredes, J Mera… - … England Journal of …, 2022 - Mass Medical Soc
Background Remdesivir improves clinical outcomes in patients hospitalized with moderate-
to-severe coronavirus disease 2019 (Covid-19). Whether the use of remdesivir in …

[HTML][HTML] Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

M Wang, R Cao, L Zhang, X Yang, J Liu, M Xu, Z Shi… - Cell research, 2020 - nature.com
In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged
in Wuhan, a city of 11 million people in central China. The initial cases were linked to …

Remdesivir for the treatment of Covid-19

JH Beigel, KM Tomashek, LE Dodd… - … England Journal of …, 2020 - Mass Medical Soc
Background Although several therapeutic agents have been evaluated for the treatment of
coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be …

Remdesivir for the treatment of Covid-19—preliminary report

JH Beigel, KM Tomashek, LE Dodd… - … England Journal of …, 2020 - discovery.ucl.ac.uk
BACKGROUND: Although several therapeutic agents have been evaluated for the treatment
of coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be …

Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID‐19) implicate special control measures

Y Wang, Y Wang, Y Chen, Q Qin - Journal of medical virology, 2020 - Wiley Online Library
By 27 February 2020, the outbreak of coronavirus disease 2019 (COVID‐19) caused 82 623
confirmed cases and 2858 deaths globally, more than severe acute respiratory syndrome …

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

G Li, E De Clercq - Nature reviews Drug discovery, 2020 - nature.com
Therapeutic options for the 2019 novel coronavirus (2019-nCoV) Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned?

NC Peeri, N Shrestha, MS Rahman… - International journal …, 2020 - academic.oup.com
Objectives To provide an overview of the three major deadly coronaviruses and identify
areas for improvement of future preparedness plans, as well as provide a critical …

Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations

J Phua, L Weng, L Ling, M Egi, CM Lim… - The lancet respiratory …, 2020 - thelancet.com
Summary As coronavirus disease 2019 (COVID-19) spreads across the world, the intensive
care unit (ICU) community must prepare for the challenges associated with this pandemic …