Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

Compacted, transcriptionally repressed chromatin, referred to as heterochromatin,
represents a major fraction of the higher eukaryotic genome and exerts pivotal functions of …

Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …

DNA methylation is extensively remodeled during mammalian gametogenesis and
embryogenesis. Most transposons become hypomethylated, raising the question of their …

The induction of pluripotent stem cells (iPSCs) by defined factors is poorly understood
stepwise. Here, we show that histone H3 lysine 9 (H3K9) methylation is the primary …

Dynamic changes in histone modification are critical for regulating DNA double-strand break
(DSB) repair. Activation of the Tip60 acetyltransferase by DSBs requires interaction of Tip60 …

The discovery of Suv39h1, the first SET domain-containing histone lysine methyltransferase
(HKMT), was reported in 2000. Since then, research on histone methylation has progressed …

Posttranslational histone modifications are important for gene regulation, yet the mode of
propagation and the contribution to heritable gene expression states remains controversial …

Heterochromatin is required to restrict aberrant expression of retrotransposons, but it
remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h …

Protein lysine methyltransferases G9a and GLP modulate the transcriptional repression of a
variety of genes via dimethylation of Lys9 on histone H3 (H3K9me2) as well as …