Simple Summary Glioblastoma multiforme (GBM) is one of the most aggressive
malignancies, accounting for 14.5% of all central nervous system tumors and 48.6% of …

N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …

Cancer stem cells (CSCs), known also as tumor-initiating cells, are quiescent, pluripotent,
self-renewing neoplastic cells that were first identified in hematologic tumors and soon after …

Cancer is driven by incremental changes that accumulate, eventually leading to oncogenic
transformation. Although genetic alterations dominate the way cancer biologists think about …

Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …

Background PTEN is one of the most frequently mutated genes in human cancer. Although
the roles of canonical PTEN protein and PTEN isoforms have been extensively explored, the …

Osteosarcoma (OS) is one of the most common bone cancers that constantly affects
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …

Mammalian target of rapamycin (mTOR) is a Ser/Thr kinase that regulates a wide range of
functions, including cell growth, proliferation, survival, autophagy, metabolism, and …

Diabetic polyneuropathy (DPN) continues to be generally considered as a “microvascular”
complication of diabetes mellitus alongside nephropathy and retinopathy. The microvascular …