A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

ME Perez-Muñoz, MC Arrieta, AE Ramer-Tait, J Walter - microbiome, 2017 - Springer
After more than a century of active research, the notion that the human fetal environment is
sterile and that the neonate's microbiome is acquired during and after birth was an accepted …

[HTML][HTML] Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

JR Kelly, PJ Kennedy, JF Cryan, TG Dinan… - Frontiers in cellular …, 2015 - frontiersin.org
The emerging links between our gut microbiome and the central nervous system are
regarded as a paradigm shift in neuroscience with possible implications for not only …

Leaky gut, leaky brain?

MEM Obrenovich - Microorganisms, 2018 - mdpi.com
'Leaky gut'syndrome, long-associated with celiac disease, has attracted much attention in
recent years and for decades, was widely known in complementary/alternative medicine …

The immune system and its dysregulation with aging

L Müller, S Di Benedetto, G Pawelec - … and cell biology of ageing: Part II …, 2019 - Springer
Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …

[HTML][HTML] Acute infection of viral pathogens and their innate immune escape

KR Rai, P Shrestha, B Yang, Y Chen, S Liu… - Frontiers in …, 2021 - frontiersin.org
Viral infections can cause rampant disease in human beings, ranging from mild to acute, that
can often be fatal unless resolved. An acute viral infection is characterized by sudden or …

Vulnerability of primitive human placental trophoblast to Zika virus

MA Sheridan, D Yunusov… - Proceedings of the …, 2017 - National Acad Sciences
Infection of pregnant women by Asian lineage strains of Zika virus (ZIKV) has been linked to
brain abnormalities in their infants, yet it is uncertain when during pregnancy the human …

[HTML][HTML] Linking gut microbiota to colorectal cancer

H Raskov, J Burcharth, HC Pommergaard - Journal of cancer, 2017 - ncbi.nlm.nih.gov
Pre-clinical and clinical data produce mounting evidence that the microbiota is strongly
associated with colorectal carcinogenesis. Dysbiosis may change the course of …

Mechanisms and consequences of gut commensal translocation in chronic diseases

RL Fine, S Manfredo Vieira, MS Gilmore… - Gut Microbes, 2020 - Taylor & Francis
Humans and other mammalian hosts have evolved mechanisms to control the bacteria
colonizing their mucosal barriers to prevent invasion. While the breach of barriers by …

Severe acute respiratory syndrome coronavirus 2 infection reaches the human nervous system: How?

VN Uversky, F Elrashdy, A Aljadawi… - Journal of …, 2021 - Wiley Online Library
Without protective and/or therapeutic agents the severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2) infection known as coronavirus disease 2019 is quickly …

Microbiota in obesity: interactions with enteroendocrine, immune and central nervous systems

RJ Mulders, KCG De Git, E Schéle, SL Dickson… - Obesity …, 2018 - Wiley Online Library
Western diets, with high consumption of simple sugars and saturated fats, contribute to the
rise in the prevalence of obesity. It now seems clear that high‐fat diets cause obesity, at least …