Epigenetic regulation of T cell exhaustion
Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion,
which is characterized by reduced effector function and proliferation, and the expression of …
which is characterized by reduced effector function and proliferation, and the expression of …
Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity
J Park, PC Hsueh, Z Li, PC Ho - Immunity, 2023 - cell.com
The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …
Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer
Anti-PD-1 treatment has shown unprecedented clinical success in the treatment of non-small-
cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood …
cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood …
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Naïve CD8+ T cells can differentiate into effector (Teff), memory (Tmem) or exhausted (Tex)
T cells. These developmental pathways are associated with distinct transcriptional and …
T cells. These developmental pathways are associated with distinct transcriptional and …
Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma
Interactions between T cell receptors (TCRs) and their cognate tumour antigens are central
to antitumour immune responses,–; however, the relationship between phenotypic …
to antitumour immune responses,–; however, the relationship between phenotypic …
CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer's disease pathology
Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by
innate immune-mediated inflammation, but functional and mechanistic effects of the …
innate immune-mediated inflammation, but functional and mechanistic effects of the …
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments
Tissue-resident memory T cells (TRM cells) provide protective immunity, but the
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling
INTRODUCTION More than 50% of patients treated with chimeric antigen receptor (CAR)–T
cells for B cell malignancies develop progressive disease after CAR therapy, and these …
cells for B cell malignancies develop progressive disease after CAR therapy, and these …
CD8+ T cell metabolism in infection and cancer
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …
malignant cells and can provide long-term protective immunity. In the response to infection …
[HTML][HTML] Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer
Immune checkpoint inhibitor (ICI) therapy can induce complete responses in mismatch
repair-deficient and microsatellite instability-high (d-MMR/MSI-H) colorectal cancers (CRCs) …
repair-deficient and microsatellite instability-high (d-MMR/MSI-H) colorectal cancers (CRCs) …