Dysfunctional innate immune responses and severe dengue
Although infection with the dengue virus (DENV) causes severe dengue, it causes a mild
self-limiting illness in the majority of individuals. There is emerging evidence that an …
self-limiting illness in the majority of individuals. There is emerging evidence that an …
Virus-inclusive single-cell RNA sequencing reveals the molecular signature of progression to severe dengue
Dengue virus (DENV) infection can result in severe complications. However, the
understanding of the molecular correlates of severity is limited, partly due to difficulties in …
understanding of the molecular correlates of severity is limited, partly due to difficulties in …
Immune pathogenesis of COVID-19 intoxication: storm or silence?
M Kiselevskiy, I Shubina, I Chikileva, S Sitdikova… - Pharmaceuticals, 2020 - mdpi.com
Dysregulation of the immune system undoubtedly plays an important and, perhaps,
determining role in the COVID-19 pathogenesis. While the main treatment of the COVID-19 …
determining role in the COVID-19 pathogenesis. While the main treatment of the COVID-19 …
Hyperferritinemic sepsis, macrophage activation syndrome, and mortality in a pediatric research network: a causal inference analysis
Background One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (>
500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric …
500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric …
Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes
Background: Early identification of severe dengue patients is important regarding patient
management and resource allocation. We investigated the association of 10 biomarkers …
management and resource allocation. We investigated the association of 10 biomarkers …
[HTML][HTML] Diagnosis of severe dengue: Challenges, needs and opportunities
Background Delayed diagnosis of dengue cases with increased risk for severe disease
could lead to poor disease outcome. To date there is no specific laboratory diagnostic test …
could lead to poor disease outcome. To date there is no specific laboratory diagnostic test …
[HTML][HTML] Macrophage activation marker soluble CD163 associated with fatal and severe Ebola virus disease in humans
AK McElroy, P Shrivastava-Ranjan… - Emerging Infectious …, 2019 - ncbi.nlm.nih.gov
Ebola virus disease (EVD) is associated with elevated cytokine levels, and
hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is …
hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is …
Serum ferritin level as a prognostic biomarker for predicting dengue disease severity: A systematic review and meta‐analysis
S Shukla, SM Jadhav, YK Gurav… - Reviews in Medical …, 2023 - Wiley Online Library
Serum ferritin levels serves as biomarkers in many inflammatory and infectious diseases.
This current systematic review and meta‐analysis evaluated whether serum ferritin levels …
This current systematic review and meta‐analysis evaluated whether serum ferritin levels …
sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis
Background CD163, receptor for the haptoglobin–hemoglobin complex, is expressed on
monocytes/macrophages and neutrophils. A soluble form of CD163 (sCD163) has been …
monocytes/macrophages and neutrophils. A soluble form of CD163 (sCD163) has been …
Macrophage Activation Syndrome in Viral Sepsis
Macrophage activation syndrome (MAS) is a life-threatening systemic hyperinflammatory
syndrome triggered by various infections, particularly viral infections, autoimmune disorders …
syndrome triggered by various infections, particularly viral infections, autoimmune disorders …