Designing hydrogels for controlled drug delivery

J Li, DJ Mooney - Nature Reviews Materials, 2016 - nature.com
Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery
and have found clinical use. Hydrogels can provide spatial and temporal control over the …

Harnessing endogenous stimuli for responsive materials in theranostics

AB Cook, P Decuzzi - ACS nano, 2021 - ACS Publications
Materials that respond to endogenous stimuli are being leveraged to enhance
spatiotemporal control in a range of biomedical applications from drug delivery to diagnostic …

Recent advances in shear‐thinning and self‐healing hydrogels for biomedical applications

S Uman, A Dhand, JA Burdick - Journal of Applied Polymer …, 2020 - Wiley Online Library
Shear‐thinning and self‐healing hydrogels are being investigated in various biomedical
applications including drug delivery, tissue engineering, and 3D bioprinting. Such hydrogels …

Advances in regenerative medicine and tissue engineering: innovation and transformation of medicine

K Dzobo, NE Thomford, DA Senthebane… - Stem cells …, 2018 - Wiley Online Library
Humans and animals lose tissues and organs due to congenital defects, trauma, and
diseases. The human body has a low regenerative potential as opposed to the urodele …

Regenerative medicine: Current therapies and future directions

AS Mao, DJ Mooney - … of the National Academy of Sciences, 2015 - National Acad Sciences
Organ and tissue loss through disease and injury motivate the development of therapies that
can regenerate tissues and decrease reliance on transplantations. Regenerative medicine …

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

S Mitragotri, PA Burke, R Langer - Nature reviews Drug discovery, 2014 - nature.com
The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …

Adaptable hydrogel networks with reversible linkages for tissue engineering

H Wang, SC Heilshorn - Advanced Materials, 2015 - Wiley Online Library
Adaptable hydrogels have recently emerged as a promising platform for three‐dimensional
(3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels …

Latest advances in cryogel technology for biomedical applications

A Memic, T Colombani, LJ Eggermont… - Advanced …, 2019 - Wiley Online Library
There exists a technological need for advanced materials with improved properties for
emerging biomedical applications. Recent developments in macroporous materials have …

Macroscale biomaterials strategies for local immunomodulation

MO Dellacherie, BR Seo, DJ Mooney - Nature Reviews Materials, 2019 - nature.com
The immune system plays key roles in tissue homeostatic and disease processes, and
manipulation of innate and adaptive immune responses is of great promise for a wide array …

Engineering complex tissues

A Atala, FK Kasper, AG Mikos - Science translational medicine, 2012 - science.org
Tissue engineering has emerged at the intersection of numerous disciplines to meet a
global clinical need for technologies to promote the regeneration of functional living tissues …