Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Malaria is an infectious disease caused by parasites of the genus Plasmodium, which leads
to approximately one million deaths per annum worldwide. Chemical validation of new …

The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

Tritryps diseases are devastating parasitic neglected infections caused by Leishmania spp.,
Trypanosoma cruzi and Trypanosoma brucei subspecies. Together, these parasites affect …

The promising drug target N-myristoyltransferase (NMT) catalyses an essential protein
modification thought to occur exclusively at N-terminal glycines (Gly). Here, we present high …

Neglected tropical diseases (NTDs) constitute a group of approximately 20 infectious
diseases that mainly affect the impoverished population without basic sanitation in tropical …

N-Myristoyltransferase (NMT) modulates protein function through the attachment of the lipid
myristate to the N terminus of target proteins, and is a promising drug target in eukaryotic …

Highlights•Anti-leishmanial drugs available today pose severe side effects and are not
affordable.•Identifying suitable drug target is essential for effective drug development.•Target …

N-Myristoyltransferase (NMT) covalently attaches a C14 fatty acid to the N-terminal glycine
of proteins and has been proposed as a therapeutic target in cancer. We have recently …